Activities of the Foundation

Since its establishment in 1988, the E.K. Frey – E. Werle Foundation has supported scientific conferences and symposia with nearly 600,000 US$ in total. The awards and laudation speeches have been presented by the former President of the LMU, Prof. Dr. Wulf Steinmann (1988-1995) and subsequently by Prof. Dr. Werner Müller-Esterl and Prof. Dr. Hans Fritz. Some of the laudatios have been published in Immunopharmacology 43, 91-95 (1999) and 32, 2-5 (1996) as well as in Agents & Actions, Suppl. 38/I, 8-17 (1992).

Recipients of the Awards

1988

International Symposium on the occasion of the 100th birthday anniversary of E.K. Frey: 'The Kallikrein-Kinin System in Health and Disease', Munich, Germany


Medal Ervin G. Erdös (USA)

Prize Gerd Bönner (Germany) & Walter Jauch (Germany)

1989

Symposium '20 Years of Research by SFB 51 and SFB 207 of LMU Munich' with Academic Celebration in the Aula of the LMU, Munich, Germany


Medal Robert Huber (Germany)

Prize Wolfram Bode (Germany)

Kinin '91 Munich awardees and hosts (left to right):
W. Steinmann (LMU President), R. Huber ('89 medalist),
C. Figueroa, J. Stewart, and A. Schmair ('91 awardees),
W. Bode ('89 prize winner), H. Fritz (Conference chair)

1991

International Conference KININ '91 Munich, Germany


Medal John M. Stewart (USA)

Prize Carlos D. Figueroa (Chile) & Alvin H. Schmaier (USA)

1993

International Conference KININ '93 Brazil, Guarujá (Sao Paulo), Brazil


Medal Sergio H. Ferreira (Brazil)

Prize Kurt Jarnagin (USA) & David Proud (USA)

1994

International Conference on KININS, Montreal, Canada


Medal Domenico Regoli (Canada)

Prize Bernward A. Schoelkens (Germany)

1995

International Conference KININ '95 Denver, USA


Medal Mel Schachter (UK)

Prize Julie Chao (USA) & Lee Chao (USA)

1996

International Conference KININ '96 Durban, South Africa


Medal Kanti D. Bhoola (South Africa)

1997

Gordon Research Conference on Kallikreins and Kinins, Barga, Italy


Medal Harry S. Margolius (USA)

Prize François Alhenc-Gelas (France)

1998

International Conference KININ '98, Nara, Japan


Medal Hiroshi Maeda (Japan)

Prize Fredrik Leeb-Lundberg (USA, Sweden)

Honorary Membership Silver Medal Sadaaki Iwanaga (Japan)

1998

3rd Symposium 'From Increased Energy Metabolism to Cardiac Hypertrophy and Failure', Baden-Baden, Germany


Medal Victor J. Dzau (USA)

2000

International Conference KININS 1925 - 2000 MUNICH, organized by the E.K. FREY – E. WERLE Foundation


Honorary Membership Silver Medal Oscar A. Carretero (USA)
Judith Clements (Australia)
Robert W. Colman (USA)
Alan W. Cuthbert (England)
Günther Dietze (Germany)
Lowell M. Greenbaum (USA)
Sadaaki Iwanaga (Japan)
Allen P. Kaplan (USA)
Makoto Katori (Japan)
Klaus Peter (Germany)
Claudio A. M. Sampaio (Brazil)
Kazuaki Shimamoto (Japan)

2002

International Conference KININ '02, Charleston, USA


Medal Hans Fritz (Germany)

Prize Fred Hess (USA)

2005

1st International Conference 'Exploring the Future of Local Vascular and Inflammatory Mediators', Lund, Sweden


Medal Rudi Busse (Germany)

Prize François Marceau (Canada)

2007

KININ 2007: 2nd International Conference 'Exploring the Future of Vascular and Inflammatory Mediators', Berlin, Germany


Medal Oliver Smithies (USA)

Prize João Pesquero (Brazil)

2007

2nd International Symposium on 'Kallikreins & Kallikrein-related Peptidases', Santorini Island, Greece


Medal Judith Clements (Australia)

2007

5th General Meeting of the International Proteolysis Society, Patras, Greece


Medal Eleftherios Diamandis (Canada)

2008

43rd Annual Meeting of the German Diabetes Association, Munich, Germany


Medal Erik John Henriksen (USA)

2009

5th International Symposium on Peptide Receptors & KININ 2009, Québec City, Canada


Medal Werner Müller-Esterl (Germany)
Oscar Carretero (USA)

Prize Nancy Brown (USA)

2009

3rd International Symposium on Kallikreins and Kallikrein-related Petidases, Munich, Germany


Medal Michael Blaber (USA)

Prize Andreas Scorilas (Greece)

Young Investigator Award Katerina Oikonomopoulou (Canada)

2011

4th International Symposium on Kallikreins and Kallikrein-related Peptidases, Rhodes Island, Greece


Prize Viktor Magdolen (Germany)

Young Investigator Award Konstantinos Mavridis (Greece)

2012

3rd International Symposium on Vasoactive and Inflammatory Mediators - KININ 2012, Paris, France


Medal Pierre Corvol (France)

Prize Randal Skidgel (USA)

Young Investigator Award Maria Campos (Brazil)

2013

5th International Symposium on Kallikreins and Kallikrein-related Peptidases, Toronto, Canada


Medal Morley D. Hollenberg (Canada)

Prize Georgia Sotiropoulou (Greece)

Young Investigator Award Ulf Meyer-Hoffert (Germany)

2015

International Meeting Kinin System and Peptide Receptors - KININ 2015 Brazil, São Paulo


Medal Michael Bader (Germany)

Prize Ronaldo de Carvalho Araujo (Brazil)

Membership Silver Medal João Calixto Batista (Brazil)

2015

6th International Symposium on Kallikreins and Kallikrein-Related Peptidases KLKs, ISK 2015 Brisbane, Australia


Medal Manfred Schmitt (Germany)

Prize Isobel Scarisbrick (USA)

2017

7th International Symposium on Kallikreins and Kallikrein-Related Peptidases, ISK 2017 Tours, France


Medal George Yousef (Canada)

Prize Peter Goettig (Austria)

Young Investigator Award Thomas Kryza (Australia)

 

 

Rationale of the Awards of the Recipients

E.K. Frey - E. Werle Commemorative Gold Medalists

 

Medalists

Major Topics

1988 Ervin Erdös
USA
Peptide hormone cleaving enzymes
Kininases
1989 Robert Huber
Germany
Structures and functions of proteases and protease inhibitors
1991 John Stewart
USA
Design and synthesis of kinin agonists and antagonists
1993 Sergio Ferreira
Brazil
ACE inhibition by bradykinin potentiating peptides
Antihypertensives and peripheral analgesics
1994 Domenico Regoli
Canada
Receptor pharmacology of kinins and other neuropeptides
1995 Mel Schachter
UK
Comparative pharmacology of bradykinin, kallidin and wasp kinin (KININ term introduced)
1996 Kanti Bhoola
South Africa
Functional roles of kinins and their molecular mechanisms of action
Localization of components of the KKS
1997 Harry Margolius
USA
KKS in hypertension, diabetes, epithelial transport and central nervous system
1998 Hiroshi Maeda
Japan
KKS in infectious diseases and inflammation
Parasitic proteases and KKS
1999 Victor Dzau
USA
Physiology and pathophysiology of the renin-angiotensin system
2002 Hans Fritz
Germany
Structures, functions and biological roles of kallikreins, proteases and their inhibitors
2005 Rudi Busse
Germany
Endothelium: Control of vascular tone and homeostasis (kinins, NO)
2007 Oliver Smithies
USA
Gene targeting technology: Role of kinins and other cardiovascular hormones
2007 Judith Clements
Australia
Gene locus of tissue kallikrein family
KLK peptidases in hormone-dependent cancers
2007 Eleftherios Diamandis
Canada
Tissue kallikrein gene family
KLK peptidases as cancer biomarkers
2008 Eric Henriksen
USA
Significance of the RAS und KKS in the modulation of insulin action in skeletal muskle tissue
2009 Werner Müller-Esterl
Germany
Kininogens, kinin receptors, and ACE inhibitors: Structures and functions
2009 Oscar Carretero
USA
KKS and RAS in blood pressure regulation, renal function, and organ damage
2009 Michael Blaber
USA
KLK peptidases: Structural biology, enzymology and activation profiles
2012 Pierre Corvol
France
Renin-angiotensin system: structures, genetics, physiology and pathophysiology
2013 Morley Hollenberg
Canada
Biological functions of KLKs and PARs
2014 Ervin G. Erdös
USA
Gold Medalist 1988: "Pioneer in Medicine Award of the University of Chicago"
2015 Michael Bader
Germany
Molecular biology of genes coding for cardiovascular hormones
Development of transgenic technology in mouse and rat
2015 Manfred Schmitt
Germany
Role and clinical relevance of proteolysis systems in gynecological tumors
Clinical utility of KLK family members for prognosis of breast and ovarian cancer patients
2017 George M. Yousef
Canada
Cloning of  7 novel KLK peptidase genes
Characterization of the complete human kallikrein locus on chromosome 19
Expression pattern of KLK genes in human tissues



E.K. Frey - E. Werle Promotion Prize Recipients

 

Recipients

Major Topics

1988 Gerd Bönner
Germany
Renal KKS in arterial hypertony
Clinical pharmacology of ACE inhibitors
  Karl-Walter Jauch
Germany
Kinins & ACE inhibitors in regenerative metabolism
1989 Wolfram Bode
Germany
Proteinases, inhibitors, substrates: Xray structures, molecular mechanism of interactions
1991 Carlos Figueroa
Chile
Cellular localization of tissue-kallikreins and kininogens
Role of the KKS in the inflammatory response
  Alvin H. Schmaier
USA
Kininogens: Functions, reaction mechanisms, interactions with coagulant and inflammatory cells
1993 Kurt Jarnagin
USA
The bradykinin receptor: Molecular biology and pharmacology
  David Proud
USA, Canada
Role of kinins in the pathogenesis of allergic rhinitis as base for new therapeutic approaches
1994 Bernward Schölkens
Germany
Clinical efficacy of bradykinin receptor antagonists
Cardioprotective effects of ACE inhibitors
1995 Julie Chao
USA
Kallistatin, a new member of the serpin superfamily: Biochemistry, molecular biology, physiological function
  Lee Chao
USA
Tissue kallikrein genes: Cloning, characterization, regulation, targeting to animal models for therapeutic approaches
1997 François Alhenc-Gelas
France
Cloning and function of ACE, ACE gene polymorphism
ACE as a cardiovascular and renal risk factor
1998 Fredrik Leeb-Lundberg
USA, Sweden
Kinin receptors: Ligand binding, intracellular trafficking
Kinin stimulated cellular pathways
2002 Fred Hess
USA
Mammalian kinin receptors: Cloning, expression, structural/functional characterization, gene targeting
2005 François Marceau
Canada
Kinin receptors: Molecular architecture, functional role in patho/physiology, therapeutic potential
2007 João Pesquero
Brazil
Molecular biology of kinin receptors
Patho/physiology of the KKS in transgenic knockout animal models
2009 Nancy Brown
USA
Cardiovascular effects of the KKS in humans in health and disease
2009 Andreas Scorilas
Greece
Clinical relevance of KLK peptidases, novel cancer- and apoptosis-related genes
2011 Viktor Magdolen
Germany
Kallikrein-related petidases and the uPA system in cancer
2012 Randal Skidgel
USA
Biological role of carboxypeptidases
Novel concepts of kinin receptor signaling
2013 Georgia Sotiropoulou
Greece
Biochemical and biological aspects of KLKs
2015 Ronaldo de
Carvalho Araujo

Brazil
Role of kinin B1 receptor in energy metabolism
Inflammatory responses and neutrophil homeostasis
2015 Isobel Scarisbrick
USA
Biological and clinical role of kallikrein-related peptidases KLKs in the central nervous system
Using new strategies to introduce KLKs as targets for neuronal repair
2017 Peter Goettig
Austria
Structural biology of KLK peptidases, their hierarchical post-translational modifications resulting in their conformational and proteolytic activation
Principals of the regulation of molecular activity into clinical diagnostic and therapeutic strategies for treatment of cancer
   
 

E.K. Frey - E. Werle Young Investigator Award

 

Recipients

Major Topics

2009 Katerina Oikonomopoulou
Canada
KLK peptidases: Expression in cancer and involvement in cell signalling
2011 Konstantinos Mavridis
Greece
Influence of anticancer drugs on gene expression of kallikrein-related peptidases
2012 Maria Campos
Brazil
Kinin, endothelin and chemokine receptors
Inflammatory mediators in the nervous system
2013 Ulf Meyer-Hoffert
Germany
Kazal-type protease inhibitors and KLKs
2017 Thomas Kryza
Australia
Molecular mechanisms by which KLK peptidases regulate the tumor microenvironment in lung and prostate cancers
Role of KLKs in progression and development of aggressive prostate cancers